News
Mid-Term review meeting and report
Actually the consortium is preparing the mid-term review meeting and report in order to present the development and results of the ADIBET Project to the European Commission.
The secondments are running
The exchanges of staff that the ADIBET Project planned at the beginning have started to be implemented. Are you interested in a Postdoctoral position? ADIBET consortium offers two recruitments for postdoctoral researchers to start immediately. If you are interested in more information consult the Jobs section and/or contact us.
Job opportunities
Opened the IDIBAPS Postdoctoral position to study the role of the adipose tissue in beta cell function and mass
ADIBET Project is searching a post-doctoral researcher with an experience from 4 to 10 years in order to start a nearly 2 year period in the Diabetes and Obesity Lab in IDIBAPS – Barcelona under the leadership of Prof. Ramon Gomis. Send your application: adibet.idibaps@gmail.com.
Opened the Warwick Postdoctoral position to study the role of the adipose tissue in beta cell function and mass
ADIBET Project is searching a post-doctoral researcher with an experience from 4 to 10 years in order to start a nearly 2 year period in the laboratory of Mike Khan and Stella Pelengaris in the University of Warwick. Send your application: adibet.warwick@gmail.com.
Our research
Tasks to develop
| 1- Identification of adipocyte secretion pattern – different depots and different conditions | |
Objectives: |
• Do an extensive analasys of the adipocyte transcription and secretion profile during obesity etiopathogenesis. • Detection of the differences in adipocyte function and secretion due to depot localization, sex and age. |
Implementation: |
Month 1 – Month 42 |
Deliverables: |
• Identification of the adipocyte transcriptome and secretion. • Characterization of differences in adipocyte function and secretion due to depot localization, gender and age. • Descovery of new adipokines. |
Participants: |
IDIBAPS, Warwick, Genosyst and Obetherapy |
Results: |
link |
| 2- Molecular mechanisms of beta cell adaptation to obesity | |
Objectives: |
Study the changes in the islet gene expression during the progression towards obesity |
Implementation: |
Month 1 – Month 36 |
Deliverables: |
• Characterization of the islet adaptation to an hypercaloric diet and insulin resistance. • Identify the molecular mechanisms of response to a reduction of insulin resistence in an obese animal, role of insulin signalling pathway. |
Participants: |
IDIBAPS, Warwick, Genosyst and Obetherapy |
Results: |
link |
| 3- Identification of adipokines involved in beta cell replication and apoptosis | |
Objectives: |
• Identify the factors secreted by adipose tissue which are able to control beta cell replication and apoptosis • Characterize the adipokine-mediate crosstalk with the beta cell. |
Implementation: |
Month 7 – Month 48 |
Deliverables: |
• Identification of the adipokines that control the beta cell mass homeostasis • Characterization of the molecular mechanisms of beta cell function (replication, apoptosis) |
Participants: |
IDIBAPS, Warwick, Genosyst and Obetherapy |
Results: |
link |
| 4- Data integration and druggable targets search | |
Objectives: |
• Integration of collected data for different beta cell phenotypes and states. • Identify, a limited and manageable subset of those genes/proteins predicted to offer the greatest promise as potential therapeutic targets. |
Implementation: |
Month 12 – Month 48 |
Deliverables: |
Report on a list of genes/proteins to be used as potential therapeutic targets for obesity. |
Participants: |
IDIBAPS, Warwick, Genosyst and Obetherapy |
Results: |
link |
