What is Adibet?
The project
ADIBET Project represents the shared vision of a highly respected multidisciplinary team comprising, clinicians, biologists, statisticians, mathematicians and computer scientists. Specifically, by using both a systems biology and a more traditional candidate-gene approach in parallel, we will perform a series of interrelated tasks to tackle the following goals:
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Identify the effects of obesity on adipose tissue using a systems approach |
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Characterize the specific differences in the pathophysiology of obesity in children and ageing population and between genders |
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Begin the major task of describing how these adipose cell genes/proteins are clustered (interactome) and to identify downstream functional gene/protein networks. Paying special attention to the differences observed in the different adipose tissue depots. |
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Unambiguously identify the changes in adipokine secretome accompanying the key phenotypes and physiological distribution of adipocyte to understand adipocyte plasticity. |
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Identify the molecular mechanisms by which the different adipokines influence the function of beta cell and endothelium. Determine which adipokine is responsible for what effect. |
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Identify, a limited and manageable subset of those genes/proteins predicted to offer the greatest promise as potential therapeutic targets with the aim to exploit the druggable targets. |